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  • Title: An abnormal pattern of amniotic fluid microvillar enzymes signalling fetal cystic fibrosis.
    Author: Brock DJ, Clarke HA.
    Journal: Clin Genet; 1987 Mar; 31(3):182-5. PubMed ID: 2882881.
    Abstract:
    We have observed seven pregnancies at risk for fetal cystic fibrosis where second-trimester amniotic fluid microvillar enzyme activities presented an unusual pattern. Low gamma-glutamyltranspeptidase and borderline alpha-glucosidase values were associated with normal aminopeptidase M and intestinal alkaline phosphatase values. All seven pregnancies went to term; five of the seven infants were affected with cystic fibrosis.
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