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  • Title: X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus.
    Author: Mensink EJ, Thompson A, Sandkuyl LA, Kraakman ME, Schot JD, Espanol T, Schuurman RK.
    Journal: Hum Genet; 1987 May; 76(1):96-9. PubMed ID: 2883112.
    Abstract:
    The gene involved in X-linked immunodeficiency with hyperimmunoglobulinemia M (XHM) was localized by the use of nine restriction fragment length polymorphic (RFLP) markers covering the entire X chromosome. Multipoint linkage analysis of RFLP data obtained in a three generation XHM pedigree indicates the Xq24-q27 area around the DXS42 RFLP locus as the most likely localization of the XHM locus.
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