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  • Title: Pyoderma gangrenosum and myeloproliferative disorders. Report of a case and review of the literature.
    Author: Romano J, Safai B.
    Journal: Arch Intern Med; 1979 Aug; 139(8):932-4. PubMed ID: 288320.
    Abstract:
    The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders has also been described. We describe a patient with chronic myelocytic leukemia in whom PG developed during the course of illness. We present an immunologic analysis of this case, speculation on the pathogenesis of PG, and a review of the literature. We report the futility of current therapeutic modalities in the treatment of PG.
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