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Title: An organocatalytic cis-selective approach to bicyclic δ-lactones. Author: Kowalczyk D, Albrecht Ł. Journal: Org Biomol Chem; 2017 Sep 13; 15(35):7286-7289. PubMed ID: 28832038. Abstract: A new, cis-selective, approach for the synthesis of bicyclic δ-lactones bearing a fused cyclohex-2-en-1-one moiety is described. The strategy utilizes a cascade reactivity of cyclic 1,3-diketones and 3-arylidenefuran-2(3H)-ones with the butenolide-ring-opening reaction enabling the construction of the δ-lactone framework. It benefits from broad scope, high enantioselectivity and excellent cis-diastereoselectivity.[Abstract] [Full Text] [Related] [New Search]