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  • Title: Induction of protective immunity to experimental hepatic amoebic infection in hamsters.
    Author: Chugh PS, Nain CK, Vinayak VK.
    Journal: J Hyg Epidemiol Microbiol Immunol; 1987; 31(1):99-105. PubMed ID: 2883233.
    Abstract:
    Immunisation of hamsters with the Sephadex G-200 chromatographed Fraction-I of the crude amoebic extract afforded protection in 58% of the animals against an intrahepatic challenge with a virulent subline of axenic Entamoeba histolytica NIH-200 (V). The protected animals had variable levels of anti-FI antiamoebic antibodies, while none of the infected controls had such antibodies. Findings suggest that chromatographed FI of crude amoebic extract might function as a potent immunogen affording protection in amoebic infection.
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