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  • Title: Nickel-Catalyzed Reductive Allylation of Tertiary Alkyl Halides with Allylic Carbonates.
    Author: Chen H, Jia X, Yu Y, Qian Q, Gong H.
    Journal: Angew Chem Int Ed Engl; 2017 Oct 09; 56(42):13103-13106. PubMed ID: 28834053.
    Abstract:
    The construction of all C(sp3 ) quaternary centers has been successfully achieved under Ni-catalyzed cross-electrophile coupling of allylic carbonates with unactivated tertiary alkyl halides. For allylic carbonates bearing C1 or C3 substituents, the reaction affords excellent regioselectivity through the addition of alkyl groups to the unsubstituted allylic carbon terminus. The allylic alkylation method also exhibits excellent functional-group compatibility, and delivers the products with high E selectivity.
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