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Title: [Analysis on the risk factors of diabetic foot ulcer in diabetic patients of Uyghur nationality and Han nationality in the Xinjiang Uygur Autonomous Region].
Author: Liu XL, Su FZ, Zha TJ, Liu LH, Wang ZZ, Nuerlan.
Journal: Zhonghua Shao Shang Za Zhi; 2017 Aug 20; 33(8):486-490. PubMed ID: 28835070.
Abstract:
Objective: To explore the risk factors of diabetic foot ulcer (DFU) in diabetic patients of Uyghur nationality and Han nationality in the Xinjiang Uygur Autonomous Region. Methods: Clinical data of 640 diabetic patients admitted to our ward from January 2015 to November 2016, conforming to the study criteria, were retrospectively analyzed. Patients were divided into DFU group (n=403) and non-DFU group (n=237) according to whether DFU occurred or not. The data of gender, age, nationality, body mass index (BMI), smoking, drinking, binge eating, triglyceride (TG), total cholesterol (TC), and high-density lipoprotein (HDL) of patients between two groups were compared with chi-square test and t test. Indexes with statistically significant differences between two groups were selected, and they were processed with non-conditional multivariate logistic regression analysis to screen the independent risk factors of DFU. The possible risk factors of DFU of patients of Uyghur nationality and Han nationality were further processed with non-conditional multivariate logistic regression analysis respectively to screen the independent risk factors of DFU of patients of Uyghur nationality and Han nationality. Results: (1) There were no statistically significant differences in gender, age, TC, and HDL of patients between two groups (with χ(2)=0.149, t values respectively 1.163, 1.033, and 1.026, P values above 0.05). There were statistically significant differences in nationality, BMI, smoking, drinking, binge eating, and TG of patients between two groups (with χ(2) values from 4.778 to 13.694, t values respectively 4.703 and 4.237, P<0.05 or P<0.01). (2) Nationality, BMI, smoking, drinking, binge eating, and TG were the independent risk factors of DFU(with odds ratios respectively 1.488, 1.527, 1.736, 1.738, 1.382, and 1.648, 95% confidence intervals respectively 1.315-3.175, 1.488-4.393, 1.834-4.675, 1.474-2.695, 1.342-4.678, and 1.105-6.747, P values below 0.05). (3) Smoking, drinking, binge eating, and TG were the independent risk factors of DFU in diabetic patients of Uyghur nationality (with odds ratios respectively 1.673, 1.387, 1.328, and 1.486, 95% confidence intervals respectively 1.384-1.765, 1.414-1.659, 1.423-1.687, and 1.150-1.670, P values below 0.05). BMI, smoking, and drinking were the independent risk factors of DFU in diabetic patients of Han nationality (with odds ratios respectively 2.442, 1.604, and 1.251, 95% confidence intervals respectively 2.223-2.699, 1.268-2.028, and 1.164-1.344, P<0.05 or P<0.01). Conclusions: Smoking, drinking, binge eating, and TG were the independent risk factors of DFU in diabetic patients of Uyghur nationality. BMI, smoking, and drinking were the independent risk factors of DFU in diabetic patients of Han nationality. 目的： 探讨新疆维吾尔自治区维吾尔族和汉族糖尿病患者发生糖尿病足溃疡(DFU)的相关危险因素。 方法： 回顾性分析2015年1月—2016年11月，笔者单位收治的符合入选标准的640例糖尿病患者病历资料。根据是否发生DFU，将患者分为DFU组403例和非DFU组237例。比较2组患者的性别、年龄、民族、体质量指数(BMI)、吸烟、饮酒、暴饮暴食、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)。对数据行χ(2)检验和t检验。选取2组患者差异有统计学意义的指标，行非条件多因素logistic回归分析，筛选发生DFU的独立危险因素。进一步分别对维吾尔族和汉族患者发生DFU可能的危险因素行非条件多因素logistic回归分析，筛选维吾尔族和汉族患者发生DFU的独立危险因素。 结果： (1)2组患者性别、年龄、TC、HDL比较，差异均无统计学意义(χ(2)＝0.149，t值分别为1.163、1.033和1.026，P值均大于0.05)，2组患者民族、BMI、吸烟、饮酒、暴饮暴食、TG比较，差异有统计学意义(χ(2)值为4.778～13.694，t值分别为4.703和4.237，P<0.05或P<0.01)。(2)民族、BMI、吸烟、饮酒、暴饮暴食、TG为糖尿病患者发生DFU的独立危险因素(比值比分别为1.488、1.527、1.736、1.738、1.382、1.648，95%置信区间分别为1.315～3.175、1.488～4.393、1.834～4.675、1.474～2.695、1.342～4.678、1.105～6.747，P值均小于0.05)。(3)吸烟、饮酒、暴饮暴食和TG是维吾尔族糖尿病患者发生DFU的独立危险因素(比值比分别为1.673、1.387、1.328、1.486，95%置信区间分别为1.384～1.765、1.414～1.659、1.423～1.687、1.150～1.670，P值均小于0.05)。BMI、吸烟、饮酒是汉族糖尿病患者发生DFU的独立危险因素(比值比分别为2.442、1.604、1.251，95%置信区间分别为2.223～2.699、1.268～2.028、1.164～1.344，P<0.05或P<0.01)。 结论： 吸烟、饮酒、暴饮暴食和TG是维吾尔族糖尿病患者发生DFU的独立危险因素，BMI、吸烟、饮酒是汉族糖尿病患者发生DFU的独立危险因素。.

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