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  • Title: Effect of antidepressant and neuroleptic drugs on the electrically evoked release of serotonin from rat cerebral cortex.
    Author: Gross G, Hante K, Göthert M.
    Journal: Psychopharmacology (Berl); 1987; 91(2):175-81. PubMed ID: 2883696.
    Abstract:
    The effect of antidepressant and neuroleptic drugs on the electrically evoked release of serotonin (5-HT) was investigated in rat brain cortical slices preincubated with 0.1 mumol/l 3H-5-HT. Zimelidine, trazodone, clomipramine, doxepin, and viloxazine (1 mumol/l each) enhanced the electrically-induced 3H overflow by 20-44%. Six other antidepressants and five neuroleptics did not increase the evoked transmitter release. Only trazodone and viloxazine also increased the 3H overflow in experiments in which neuronal 5-HT reuptake was already blocked by 6-nitroquipazine. 5-HT and clonidine inhibited the electrically-induced 3H-5-HT release by stimulation of presynaptic 5-HT autoreceptors and alpha 2-adrenoceptors, respectively; trazodone and viloxazine had no effect on the concentration-response curves of 5-HT and clonidine. Other psychotropic agents with well known antiserotonergic activities also failed to block presynaptic 5-HT autoreceptors. It is concluded that zimelidine, clomipramine, and doxepin enhanced the 3H-5-HT overflow by inhibition of neuronal 5-HT uptake, whereas the increase produced by trazodone and viloxazine cannot be explained by reuptake inhibition or interaction with presynaptic receptors.
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