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  • Title: [Acquired deficiencies in antithrombin III and C protein during treatment with L-asparaginase].
    Author: Mielot F, Danel P, Boyer C, Coulombel L, Dommergues JP, Tchernia G, Larrieu MJ.
    Journal: Arch Fr Pediatr; 1987 Mar; 44(3):161-5. PubMed ID: 2883953.
    Abstract:
    Fourteen children treated by L-Asparaginase for acute lymphoblastic leukemia had sequential coagulation studies performed including cephalin-kaolin time, Quick time, fibrinogen, factors II, VII + X and V, as well as antithrombin III and protein C, the major coagulation inhibitors. A severe antithrombin III and protein C deficiency was observed during therapy, with a coexisting hypocoagulability. This equilibrium partially explains the lack of thrombo-embolic phenomena in these children, despite the risk factors present. Although no substitutive therapy was instituted in these cases, their use in high-risk cases is discussed.
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