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  • Title: Serum ovarian steroids, prolactin and prostaglandin metabolites in women using the inert intrauterine device.
    Author: Shalev E, Harpaz-Kerpel S, Engelhard Y, Weiner E, Eran A, Zuckerman H.
    Journal: Int J Gynaecol Obstet; 1987 Apr; 25(2):139-44. PubMed ID: 2884139.
    Abstract:
    Serum levels of 17 beta estradiol, progesterone, prolactin and metabolites of prostaglandins E2 and F2a were investigated in 18 healthy women before and after the insertion of a Saf-T-Coil intrauterine device. The results suggest that the presence of an intrauterine device may cause hormonal changes affecting the luteal phase of the menstrual cycle. Despite a long clinical history of use of the inert IUD as a contraceptive, the hormonal changes whch may accompany its use are not yet entirely clear. Serum levels of 17 beta estradiol, progesterone, prolactin and metabolites of prostaglandins E2 and F2a were investigated in 18 healthly women before and after the insertion of a Saf-T-Coil intrauterine device. The present data shows a 3-days shift to the right of estrogen dip and rise with clinical shortening of the luteal phase. Serum level of both steroids was found to be significantly lower in the luteal phase and at the time of menstruation. In the present study significant increase in the level of prolactin was found at the luteal phase. Besides ovarian steroids and prolactin, prostaglandins were also implicated in the contraceptive effect of the IUD. The results suggest that the presence of an IUD may cause hormonal changes affecting the luteal phase of the menstrual cycle.
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