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  • Title: Oocyte-specific expression and developmental regulation of ZP3, the sperm receptor of the mouse zona pellucida.
    Author: Philpott CC, Ringuette MJ, Dean J.
    Journal: Dev Biol; 1987 Jun; 121(2):568-75. PubMed ID: 2884155.
    Abstract:
    The mouse zona pellucida is composed of three sulfated glycoproteins, encoded by the oocyte genome, that have important biological functions in preimplantation development. One of the zona gene products, ZP3, functions as the sperm receptor at fertilization. Our present data demonstrate that the ZP3 gene is transcribed in oocytes where its expression is developmentally regulated. Resting primordial oocytes do not express ZP3 mRNA, but these transcripts rapidly accumulate in growing oocytes so that they represent 0.1-0.2% of the total poly(A+) RNA. As oocytes complete their growth and undergo meiotic maturation, the abundance of ZP3 transcripts falls off dramatically; ovulated eggs contain less than 15% of peak levels. The oocyte-specific accumulation of ZP3 transcripts serves as an attractive system for further studies of factors that modulate developmentally regulated genes during mammalian oogenesis.
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