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  • Title: The protective effect of cimetidine on stress-induced acute gastric ulceration in the rat.
    Author: King RW, Korman MG, Taggart GJ, Hansky J.
    Journal: Aust N Z J Surg; 1979 Feb; 49(1):129-30. PubMed ID: 288417.
    Abstract:
    The effect of intraperitoneal cimetidine, an H2 receptorantagonist, has been assessed on the development of cold-restraint induced acute gastric ulcers in rats. Cimetidine in doses ranging from 20-100 mg per kg body weight significantly reduced the incidence of acute gastric ulceration compared with saline controls in this model. The protective effect of cimetidine suggests a prophylactic role for this agent in stress-induced gastric or duodenal ulceration in man.
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