These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Neurotransmitter-stimulated inositol phosphate accumulation in hippocampal slices.
    Author: Labarca R, Janowsky A, Paul SM.
    Journal: Methods Enzymol; 1987; 141():192-201. PubMed ID: 2885715.
    Abstract:
    The agonist-induced accumulation of [3H]IP in the presence of lithium represents a sensitive method for studying a number of receptor-mediated events in brain. In the presence of lithium, receptor-mediated [3H]IP3 formation in brain is difficult to demonstrate. It is possible that lithium itself may prevent the formation if IP3 and, thus, the presence of lithium in the incubation may account for such a discrepancy. It is likely that the effects of lithium on the PI cascade are more complex then previously envisioned. The recent identification of the inositol polyphosphates, myo-inositol 1,3,4-trisphosphate and myo-inositol 1,3,4,5-tetrakisphosphate, indicates that other inositol phosphates need to be considered in future studies of receptor-mediated PI metabolism.
    [Abstract] [Full Text] [Related] [New Search]