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  • Title: Rapid eye movement sleep in man: modulation by benzodiazepines.
    Author: Belyavin A, Nicholson AN.
    Journal: Neuropharmacology; 1987 May; 26(5):485-91. PubMed ID: 2885771.
    Abstract:
    The modulation of rapid eye movement REM sleep in man by benzodiazepines has been analysed using 366 sleep recordings with at least 3 REM periods, obtained in 25 individuals, over 9 years. Sleep-dependent and sleep-independent mechanisms are believed to control REM activity, and the effect of benzodiazepines can be explained if the sleep-dependent influence is modified. It is suggested that a negative feedback mechanism, which usually encourages the appearance of REM periods, is depressed, while a threshold and oscillator which determine the cyclical appearance of the activity, and its relation with the onset of sleep, are unaffected.
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