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  • Title: Spontaneous Healing of Clodronate-Related Osteonecrosis of the Jaw.
    Author: Nastro Siniscalchi E, Allegra A, De Ponte FS, Oteri G, Cervino G, Lauritano F, Musolino C, Cicciù M.
    Journal: J Craniofac Surg; 2017 Oct; 28(7):e687-e689. PubMed ID: 28857991.
    Abstract:
    Cases of medication-related osteonecrosis of the jaw (MRONJ) have been more commonly associated with aminobiphosphonate therapy than with alkylbiphosphonate treatment. Here, we report a case of MRONJ in a subject who received an alkylbiphosphonate, clodronate, for the treatment of osteoporosis, and discuss the pathogenic mechanisms of alkylbiphosphonates and the possible reasons for the spontaneous and rapid remission of MRONJ occurring in our patient.
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