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  • Title: A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma.
    Author: Chowdhry AK, Fung C, Chowdhry VK, Bergsma D, Dhakal S, Constine LS, Milano MT.
    Journal: Leuk Lymphoma; 2018 May; 59(5):1180-1187. PubMed ID: 28862484.
    Abstract:
    Hodgkin lymphoma (HL) survivors are at increased risk of thyroid cancer (TC). We sought to determine whether increased risks of high-risk pathology or mortality are seen with thyroid cancer after HL (HL-TC) compared with first primary thyroid cancer (TC-1). From the Surveillance, Epidemiology and End Results (SEER) registry, we compared patient and tumor characteristics as well as survival outcomes between HL-TC and TC-1 and fit a multivariable Cox model to assess for a possible association between HL history and overall survival after TC. Among 139,297 TC-1 and 174 HL-TC patients, history of HL was not associated with anaplastic or sarcoma TC. Multivariable analyzes showed that history of HL was not associated with a difference in risk of death after TC (hazard ratio: 0.96, 95% confidence interval: (0.81, 1.13), p = .61). Despite a significantly increased risk of TC among HL survivors, prior HL is not associated with more aggressive pathologic subtypes or worse prognosis.
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