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  • Title: The heme biosynthetic pathway in the regenerating rat liver. The relation between enzymes of heme synthesis and growth.
    Author: Schoenfeld N, Mamet R, Epstein O, Lahav M, Lurie Y, Atsmon A.
    Journal: Eur J Biochem; 1987 Aug 03; 166(3):663-6. PubMed ID: 2886336.
    Abstract:
    Enzymes of heme synthesis, porphyrins and heme content of regenerating rat livers were examined. During the first three days of regeneration the weights of livers of one-third and two-third hepatectomized rats increased 1.5-fold and 2.7-fold and the activity of porphobilinogen deaminase increased 2-fold and 4-fold and was inversely correlated with ferrochelatase activity. delta-Aminolevulinic acid synthase and delta-aminolevulinic acid dehydratase activities were reduced. Concomitantly an increase in the concentration of porphyrins and a decrease in that of heme were observed. The changes in the biosynthetic pathway of heme during rapid growth of the liver are discussed.
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