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  • Title: Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate.
    Author: Sauvageau J, Bhasin M, Guo CX, Adekoya IA, Gray-Owen SD, Oscarson S, Guazzelli L, Cox A.
    Journal: Carbohydr Res; 2017 Oct 10; 450():38-43. PubMed ID: 28866079.
    Abstract:
    d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that allows detection of Gram-negative bacteria by the mammalian immune system. Cellular detection of HBP depends upon its stimulation of a cascade that leads to the phosphorylation and assembly of the TRAF-interacting with forkhead-associated domain protein A (TIFA), which activates the transcription factor NF-κB. In this note, an alternate chemical synthesis of HBP is described and its biological activity is established, providing pure material for further assessing and exploiting the biological activity of this compound.
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