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  • Title: Sulfasalazine and its metabolites attenuate respiratory burst of leukocytes--a possible mechanism of anti-inflammatory effects.
    Author: Suematsu M, Suzuki M, Miura S, Nagata H, Oshio C, Asakura H, Watanabe M, Tsuchiya M.
    Journal: J Clin Lab Immunol; 1987 May; 23(1):31-3. PubMed ID: 2886669.
    Abstract:
    The effects of sulfasalazine and its metabolites, 5-amino salicylic acid and sulfapyridine on respiratory burst of polymorphonuclear leukocytes were investigated by determining not only luminol-dependent chemiluminescence for the detection of myeloperoxidase-mediated active oxidants, but also lucigenin-dependent chemiluminescence for the detection of superoxide anion. The present study showed that sulfasalazine, 5-amino salicylic acid and sulfapyridine attenuated active oxygen species from polymorphonuclear leukocytes at the concentrations comparable to clinical doses. Therefore, it was concluded that anti-inflammatory effects of sulfasalazine can be explained by the ability of sulfasalazine and its degraded compounds to scavenge active oxidants from polymorphonuclear leukocytes.
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