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  • Title: Somatostatin suppresses plasma aldosterone concentration in a case of Bartter's syndrome.
    Author: Shigeta H, Tasaki N, Kitazumi S, Kitagawa Y, Nakano K, Kanatsuna T, Kondo M.
    Journal: Endocrinol Jpn; 1987 Apr; 34(2):309-12. PubMed ID: 2887425.
    Abstract:
    The study was conducted to examine the effect of somatostatin on activated renin-angiotensin-aldosterone system in a case of Bartter's syndrome. After 60 minutes of 500 micrograms of somatostatin infusion, the plasma aldosterone concentration was reduced from the basal level of 250 pg/ml to 140 pg/ml, whereas plasma renin activity remained at the basal level. This result suggests that somatostatin may specifically inhibit aldosterone secretion in Bartter's syndrome and the agent can be applied to a treatment of this syndrome.
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