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  • Title: Serological response to the P fimbriae of uropathogenic Escherichia coli in pyelonephritis.
    Author: de Ree JM, van den Bosch JF.
    Journal: Infect Immun; 1987 Sep; 55(9):2204-7. PubMed ID: 2887515.
    Abstract:
    Uropathogenic Escherichia coli strains isolated from four patients with pyelonephritis were characterized by their O:K serotype, hemolysin production, mannose-resistant hemagglutination, and the serotype of the P fimbriae. These P fimbriae were serotyped with specific monoclonal antibodies. Serum samples from the patients were analyzed for the presence of specific antibodies to the P fimbriae. In all cases antifimbrial antibodies were found, strongly suggesting that these P fimbriae are expressed in vivo. However, the antibodies in the patient sera were not able to inhibit the mannose-resistant hemagglutination. This finding suggests that these antibodies react with the fimbrial components and not with the minor components which are responsible for adhesion.
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