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  • Title: SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis.
    Author: Cui Z, Tong A, Huo Y, Yan Z, Yang W, Yang X, Wang XX.
    Journal: BMC Biol; 2017 Sep 11; 15(1):80. PubMed ID: 28893254.
    Abstract:
    BACKGROUND: Similar to other eukaryotes, splicing is emerging as an important process affecting development and stress tolerance in plants. Ski-interacting protein (SKIP), a splicing factor, is essential for circadian clock function and abiotic stress tolerance; however, the mechanisms whereby it regulates flowering time are unknown. RESULTS: In this study, we found that SKIP is required for the splicing of serrated leaves and early flowering (SEF) pre-messenger RNA (mRNA), which encodes a component of the ATP-dependent SWR1 chromatin remodeling complex (SWR1-C). Defects in the splicing of SEF pre-mRNA reduced H2A.Z enrichment at FLC, MAF4, and MAF5, suppressed the expression of these genes, and produced an early flowering phenotype in skip-1 plants. CONCLUSIONS: Our findings indicate that SKIP regulates SWR1-C function via alternative splicing to control the floral transition in Arabidopsis thaliana.
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