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Title: 2-substituted tetralin derivatives as conformationally restricted butyrophenone analogs. Author: Chan CC, Farmer PS, McKenzie G, Robertson H. Journal: Pharmazie; 1987 Jun; 42(6):369-71. PubMed ID: 2890175. Abstract: Five related derivatives of 2-(2-piperidinoethyl)tetralin have been synthesized as partially rigid analogs of the neuroleptic butyrophenones. Their in vitro dopamine receptor binding properties and in vivo inhibition of dexamphetamine-induced locomotor activity are described. 1-Phenyl-2-(2-piperidinoethyl)-3,4-dihydronaphthalene hydrochloride (8) is about 1% as potent as haloperidol.[Abstract] [Full Text] [Related] [New Search]