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  • Title: [Morphofunctional state of the APUD-system cells of the lungs in hyaline membrane disease of newborn infants].
    Author: Bubnova NI.
    Journal: Arkh Patol; 1987; 49(8):47-52. PubMed ID: 2890337.
    Abstract:
    Examination of these cells in newborn infants with hyaline membrane disease. (HMD) has demonstrated involvement of neuroendocrine elements in its patho- and morphogenesis. A crucial factor in HMD development is immaturity of the lungs, one sign of which is the presence of numerous serotonin-containing cells. Degranulation of APUD cells and serotonin lease under exposure to pathogenic factors initiate pathologic reactions in the lungs and account for the earliest manifestations of the disease.
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