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  • Title: Linkage relationships of X-linked choroideremia to DXYS1 and DXS3.
    Author: MacDonald IM, Sandre RM, Wong P, Hunter AG, Tenniswood MP.
    Journal: Hum Genet; 1987 Nov; 77(3):233-5. PubMed ID: 2890569.
    Abstract:
    Choroideremia is a distinct blinding condition with an X-linked pattern of inheritance. We have analyzed two RFLPs, DXS3 and DXYS1, for linkage with the choroideremia locus (TCD) within three kindreds. A maximum LOD score of 3.98 was obtained at theta = 0.14 for TCD:DXS3. The summed maximum LOD score from this study and from previously published TCD:DXYS1 data is 5.23 at theta = 0.05. Contrary to previous reports, the present data demonstrate that these two RFLPs are not tightly linked to the choroideremia gene locus.
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