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  • Title: Controlled trial of endoscopic sclerosis in bleeding peptic ulcers.
    Author: Panés J, Viver J, Forné M, Garcia-Olivares E, Marco C, Garau J.
    Journal: Lancet; 1987 Dec 05; 2(8571):1292-4. PubMed ID: 2890900.
    Abstract:
    Of 113 patients in whom endoscopy revealed a bleeding gastric or duodenal ulcer 55 were randomly allocated to receive endoscopic sclerosis (ES) (injections of adrenaline/polidocanol) plus cimetidine while 58 received cimetidine alone as controls. 3 patients treated with ES (5.5%) compared with 25 controls (43.1%) had a major recurrent haemorrhage during their hospital stay. ES also led to significant reductions in the need for emergency surgery (3 vs 20 patients), transfusion requirements (mean 0.42 [SD 1.1] vs 2.7 (3.19) U), and the length of hospital stay (11.6 [5.1] vs 16.2 [11.3] days). ES as an adjunct to conventional medical treatment is an effective and safe emergency therapy for gastrointestinal bleeding due to peptic ulcer.
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