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  • Title: Effect of human leukocyte interferon on HBsAg production in PLC/PRF/5 human hepatoma cell line.
    Author: Hajnická V, Stancek D.
    Journal: Acta Virol; 1987 Sep; 31(5):404-9. PubMed ID: 2891279.
    Abstract:
    We describe the effect of the natural human interferon alfa (HuIFN alfa) on HBsAg production in PLC/PRF/5 cells. Decreased HBsAg production was regularly demonstrated 48 hr after the treatment of cells with 3-300 IU of HuIFN alfa/ml; it lasted for further 24-48 hr depending from the amount of interferon (IFN) added. We found no differences in the sensitivity to HuIFN alfa of non-confluent cells as compared to cells which had reached confluency. The decrease of the extracellular HBsAg excretion seems to be due to inhibition of intracellular HBsAg formation.
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