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  • Title: Pituitary-adrenal mediation of dermorphin-induced inhibition of gastric emptying in rats.
    Author: Broccardo M.
    Journal: Eur J Pharmacol; 1987 Oct 06; 142(1):151-4. PubMed ID: 2891542.
    Abstract:
    The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined. Dermorphin given i.c.v. (1, 10, 100 ng per rat) slowed emptying in a dose-related manner. Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin. Dermorphin inhibition of gastric emptying is thus specially dependent upon intact adrenals.
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