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  • Title: Taq I-generated HLA-DQ alpha polymorphism in Japanese patients with narcolepsy.
    Author: Matsuki K, Maeda H, Juji T, Inoko H, Ando A, Tsuji K, Honda Y.
    Journal: Immunogenetics; 1988; 27(2):87-90. PubMed ID: 2891613.
    Abstract:
    Taq I-generated HLA-DQ alpha restriction fragment length polymorphism was examined in Japanese patients with narcolepsy. All patients were DR2 positive and shared a 6.0 kb fragment, although this fragment was found only in 54% of the healthy DR2-positive Japanese. This finding added the DQ alpha gene to the list of candidates for the possible narcolepsy-susceptibility gene. In contrast, there was no complete association between narcolepsy and DX alpha restriction fragment length polymorphism. These findings suggest that a narcolepsy-susceptibility gene is located closer to the DQ locus than to the DX locus.
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