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  • Title: Dodecyl sorbitan ethers as antimicrobials against Gram-positive bacteria.
    Author: Belmessieri D, Gozlan C, Duclos MC, Dumitrescu O, Lina G, Redl A, Duguet N, Lemaire M.
    Journal: Bioorg Med Chem Lett; 2017 Oct 15; 27(20):4660-4663. PubMed ID: 28917650.
    Abstract:
    A range of amphiphilic sorbitan ethers has been synthesized in two steps from sorbitan following an acetalization/hydrogenolysis sequence. These sorbitan ethers and the acetal intermediates have been evaluated as antimicrobials against Gram-negative and Gram-positive bacteria. No antimicrobial activity was observed for Gram-negative bacteria. However, the compounds bearing a linear dodecyl chain exhibit antimicrobial activity (MIC as low as 8μg/mL) against Gram-positive bacteria such as Listeria monocytogenes, Enterococcus faecalis and Staphylococcus aureus. Encouraged by these preliminary results, dodecyl sorbitan was tested against a range of resistant strains and was found to be active against vancomycin-, methicillin- and daptomycin-resistant strains (MIC=32-64μg/mL).
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