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  • Title: Synthesis and application of a highly selective copper ions fluorescent probe based on the coumarin group.
    Author: He G, Liu X, Xu J, Ji L, Yang L, Fan A, Wang S, Wang Q.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2018 Feb 05; 190():116-120. PubMed ID: 28918220.
    Abstract:
    A highly selective copper ions fluorescent probe based on the coumarin-type Schiff base derivative 1 (probe) was produced by condensation reaction between coumarin carbohydrazide and 1H-indazole-3-carbaldehyde. The UV-vis spectroscopy showed that the maximum absorption peak of compound 1 appeared at 439nm. In the presence of Cu2+ ions, the maximum peak decreased remarkably compared with other physiological important metal ions and a new absorption peak at 500nm appeared. The job's plot experiments showed that complexes of 1:2 binding mode were formed in CH3CN:HEPES (3:2, v/v) solution. Compound 1 exhibited a strong blue fluorescence. Upon addition of copper ions, the fluorescence gradually decreased and reached a plateau with the fluorescence quenching rate up to 98.73%. The detection limit for Cu2+ ions was estimated to 0.384ppm. Fluorescent microscopy experiments demonstrated that probe 1 had potential to be used to investigate biological processes involving Cu2+ ions within living cells.
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