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  • Title: Prediction of Air Entrapment in Tableting: An Approximate Solution.
    Author: Zavaliangos A, Katz JM, Daurio D, Johnson M, Pirjanian A, Alvarez-Nunez F.
    Journal: J Pharm Sci; 2017 Dec; 106(12):3604-3612. PubMed ID: 28919383.
    Abstract:
    An approximate solution is presented for the prediction of air entrapment during tableting. Assuming weak coupling of the deformation of the solid phase, the flow of interstitial air and a set of reasonable additional geometric assumptions, the general problem is reduced to 1 dimension. Experimental values of air permeability through tablet specimens of commonly used pharmaceutical excipients were obtained using a 3D printed test cell outfitted to a powder rheometer. Using these values, combined with a numerical solution of the governing partial differential equation, parametric studies are presented that demonstrate the importance of permeability, compaction speed, tablet size, and punch-die tolerance on air entrapment. In addition, a first-order approximation of the role of entrapped air on the measured radial tensile strength of formed tablets is presented.
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