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  • Title: Biochemical changes in the rat after chronic thioacetamide intoxication.
    Author: Nikolaev V, Kerimova M, Naydenova E, Ivanov E, Adjarov D.
    Journal: Toxicology; 1988 Jan; 48(1):81-5. PubMed ID: 2892287.
    Abstract:
    Male Wistar rats were given drinking water ad libitum with 0.075% thioacetamide (TAA) for 4 weeks. TAA treatment did not affect serum aminotransferase activities and total bilirubin content. The activities of 5'-nucleotidase, K+, Na+- and Mg2+-adenosine triphosphatases in liver plasma membrane preparations were strongly depressed, while that of gamma-glutamyl transferase was considerably increased. A decline in liver microsomal cytochrome P-450 and cytochrome b5 concentrations was also recorded. In contrast, the content of reduced glutathione in liver homogenate supernatant (9000 g) increased about 2-fold. As plasma membrane associated enzymes seem to be exclusively affected, the liver plasma membrane could be involved in the pathogenesis of the TAA-induced precirrhotic liver changes.
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