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  • Title: Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis.
    Author: Jiménez-Ortigosa C, Moore C, Denning DW, Perlin DS.
    Journal: Antimicrob Agents Chemother; 2017 Dec; 61(12):. PubMed ID: 28923871.
    Abstract:
    We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.
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