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  • Title: Effect of ethanol on cardiac beta-adrenoceptors.
    Author: Kwast M, Tabakoff B, Hoffman P.
    Journal: Eur J Pharmacol; 1987 Oct 27; 142(3):441-5. PubMed ID: 2892687.
    Abstract:
    Liquid diets are commonly used as vehicles for chronic administration of ethanol to rodents. After mice had consumed an ethanol-free liquid diet for either seven or eight days, the number of cardiac beta-adrenoceptors and the maximum response of adenylate cyclase to isoproterenol were decreased. This change was associated with a decrease in the number of high-affinity agonist binding sites. When mice were fed ethanol in the liquid diet, there was a further decrease in the number of cardiac low-affinity agonist (isoproterenol) binding sites, but no further change in the biochemical response to isoproterenol. The data suggest that stress and/or nutritional factors can alter the number, the coupling and the function of cardiac beta-adrenoceptors and that chronic ethanol ingestion enhances certain aspects of these changes.
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