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  • Title: Plasma fibronectin levels in normal pregnancy and pre-eclampsia: a preliminary report.
    Author: Thurnau GR, Morgan MA, Brubaker D, Romine M, Blackshaw C, Fishburne JI, Fishburne I.
    Journal: Int J Gynaecol Obstet; 1987 Dec; 25(6):441-4. PubMed ID: 2892701.
    Abstract:
    Fibronectin, a major component of the extracellular matrix and basement membranes throughout the body, is thought to maintain the integrity of both the reticulo-endothelial system and microvasculature. In this study, plasma fibronectin levels were assayed by nephelometry in nine pre-eclamptic gravid women, nine normotensive gravid women and ten non-gravid women. The mean plasma fibronectin level (+/-S.E.M.) in pre-eclamptic gravidas (1687 +/- 101 micrograms/ml) is significantly higher than that of either normotensive gravidae (1129 +/- 99 micrograms/ml) or non-gravid women (897 +/- 60 micrograms/ml). Although the mechanism for elevated levels of plasma fibronectin in patients with pre-eclampsia is not clear, it may serve as an early biochemical marker for this disorder.
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