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  • Title: Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension.
    Author: de Beus E, de Jager RL, Beeftink MM, Sanders MF, Spiering W, Vonken EJ, Voskuil M, Bots ML, Blankestijn PJ, SYMPATHY study group.
    Journal: J Clin Hypertens (Greenwich); 2017 Nov; 19(11):1125-1133. PubMed ID: 28929577.
    Abstract:
    The effect of lowering sympathetic nerve activity by renal denervation (RDN) is highly variable. With the exception of office systolic blood pressure (BP), predictors of the BP-lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24-hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension. Both 24-hour ambulatory and office BP measurements were end points. No relationship was found for baseline sodium excretion and change in BP 6 months after RDN in multivariable-adjusted regression analysis. Change in the salt intake-measured BP relationships at 6 months vs baseline was used as a measure for salt sensitivity. BP was 8 mm Hg lower with similar salt intake after RDN, suggesting a decrease in salt sensitivity. However, the change was similar in the control group, and thus not attributable to RDN.
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