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  • Title: Lateralized neuroleptic-induced side effects are associated with asymmetric visual evoked potentials.
    Author: Tomer R, Mintz M, Kempler S, Sigal M.
    Journal: Psychiatry Res; 1987 Dec; 22(4):311-8. PubMed ID: 2893405.
    Abstract:
    Recent studies suggest that neuroleptic drugs may have an asymmetric effect on the two cerebral hemispheres. This effect is reflected by emergence of drug-induced lateralized extrapyramidal side effects and by dose-related alterations in electrophysiological asymmetries. The present study examined the hypothesis that asymmetry of visual evoked potentials (VEPs) is associated with lateralized appearance of neuroleptic-induced parkinsonism or tardive dyskinesia (TD). The asymmetry of the amplitudes of later VEP components was significantly higher in patients with lateralized side effects (n = 8) than in patients with symmetrical side effects (n = 6) or free of extrapyramidal side effects (n = 11). The possibility that VEP asymmetry reflects the differential degree to which the two hemispheres are affected by medication is discussed.
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