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  • Title: [Chemical constituents from ripe fruit of Cornus officinalis].
    Author: Ye XS, He J, Zhang JL, Pang XB, Zhang L, Qiao HY, Pan XG, Zhang J, Liu SN, Zhang WK, Xu JK.
    Journal: Zhongguo Zhong Yao Za Zhi; 2016 Dec; 41(24):4605-4609. PubMed ID: 28936844.
    Abstract:
    To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), (-)-isolariciresinol 3α-O-β-D-glucopyranoside(2), apigenin (3), cirsiumaldehyde(4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside,and compounds 2-4 were obtained from the Cornus genus for the first time. Compounds 2-6 were evaluated for the viability of PC12 cells when exposed in conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/R treated PC12 cells at the concentration of 1.0 μmol•L⁻¹.
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