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  • Title: HLA-DR alpha, -DX alpha, and DR beta III gene association studies in DR3 individuals.
    Author: Gorski J, Niven MJ, Sachs JA, Mach B, Cassell PG, Festenstein H, Awad J, Hitman GA.
    Journal: Hum Immunol; 1987 Dec; 20(4):273-8. PubMed ID: 2893780.
    Abstract:
    In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukocyte antigen DR3 and close association of the DR alpha, DR beta III, and DX alpha genes. Two DR3-related preferential allelic associations have been identified, which may prove useful in family analysis as well as for investigations of DR3-related diseases.
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