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  • Title: Effects of dynorphin on the PHA-induced lymphocyte proliferation in vitro.
    Author: Barreca T, Di Benedetto G, Corsini G, Lenzi G, Puppo F.
    Journal: Immunopharmacol Immunotoxicol; 1987; 9(4):467-75. PubMed ID: 2893820.
    Abstract:
    The effect of the opioid peptide dynorphin (DYN) on PHA-induced lymphocyte proliferation has been evaluated in the present study. A significant increase in PHA-induced lymphocyte activation was observed when DYN was added to cultures 48 hr after the mitogenic stimulation. This effect occurred at suboptimal (3.12 and 6.25 micrograms/ml) PHA concentrations and at DYN doses ranging from 10(-9) to 10(-12) M. Conversely, DYN did not affect the lymphocyte blastogenic process either when added before, or simultaneously or after intense PHA (12.5 micrograms/ml) stimulation. Naloxone preincubation did not modify the above described effects. Results suggest that DYN might play a role in neuroendocrine regulation of the lymphocyte blastogenic process.
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