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  • Title: Clorazepate and lorazepam: clinical improvement and rebound anxiety.
    Author: Rickels K, Fox IL, Greenblatt DJ, Sandler KR, Schless A.
    Journal: Am J Psychiatry; 1988 Mar; 145(3):312-7. PubMed ID: 2894175.
    Abstract:
    Sixty-two anxious patients were treated under double-blind conditions for 4 weeks with either clorazepate or lorazepam. Two-thirds of each treatment group were then switched abruptly to placebo for 2 weeks, while one-third continued to receive active medication. Two major findings were obtained. About 70% of the patients maintained improvement during the 2-week placebo period. Some patients, however, experienced rebound anxiety, which appeared to be more intense and occurred earlier when placebo was substituted for a benzodiazepine with a short half-life (lorazepam) than for one with a long half-life (clorazepate). The clinical relevance of these findings is discussed.
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