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  • Title: Effects of nicorandil on isolated smooth muscle cells from guinea-pig taenia caeci.
    Author: Ito Y, Obara K.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1988; 89(1):45-52. PubMed ID: 2894272.
    Abstract:
    1. The effects of nicorandil on guinea-pig taenia caeci were investigated with the use of isolated smooth muscle cells and glycerin-treated muscle fiber bundles. 2. Nicorandil inhibited high K-, Ca2+- and carbachol-induced contractions in a dose-dependent manner without affecting 45Ca fluxes in isolated cells. 3. Nicorandil had no effect on ATP-induced contraction of glycerin-treated muscle fiber bundles. 4. The present results suggest that nicorandil may inhibit the contraction by action on the contractile proteins in an indirect manner in guinea-pig taenia caeci.
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