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  • Title: Red wine as a cause of migraine.
    Author: Littlewood JT, Gibb C, Glover V, Sandler M, Davies PT, Rose FC.
    Journal: Lancet; 1988 Mar 12; 1(8585):558-9. PubMed ID: 2894493.
    Abstract:
    Patients with migraine who believed that red wine but not alcohol in general had a headache-provoking effect on them were challenged either with red wine or with a vodka and diluent mixture of equivalent alcohol content, both consumed cold out of dark bottles to disguise colour and flavour. The red wine, which had a negligible tyramine content, provoked a typical migraine attack in 9 of 11 such patients, whereas none of the 8 challenged with vodka had an attack. Neither red wine nor vodka provoked such episodes in other migrainous subjects or controls. These findings show that red wine contains a migraine-provoking agent that is neither alcohol nor tyramine.
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