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  • Title: Conserved 12-bp element downstream from mRNA polyadenylation sites.
    Author: Renan MJ.
    Journal: Gene; 1987; 60(2-3):245-54. PubMed ID: 2895038.
    Abstract:
    Sequences downstream from the AATAAA motif in a number of cellular and viral transcription units have been compared. A 12-bp conserved element was identified in approximately half of the cases studied, and a consensus sequence TTGANNNTTTTTT was derived from a comparison of 74 such sequences. This element is located immediately (5-20 bp) downstream from the poly(A)-addition site in every case where this is known, and it is suggested that this element may be involved in the cleavage/polyadenylation reaction. This proposal is consistent with published studies on deletion mutants of downstream regions.
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