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  • Title: A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata.
    Author: Liu X, Tang GH, Weng HZ, Zhang JS, Xu YK, Yin S.
    Journal: J Asian Nat Prod Res; 2018 Dec; 20(12):1123-1128. PubMed ID: 28952358.
    Abstract:
    Five selaginellin derivatives (1 and 3-6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1-6 exhibited potent activities with the IC50 values in the range of 1.04-9.35 μM.
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