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  • Title: [Screening of autoantibodies associated with necrotizing myopathy among undiagnosed chronic myopathy].
    Author: Kuru S, Suzuki S, Ogata K, Kobayashi M, Ishida C, Watanabe C, Matsumura T.
    Journal: Rinsho Shinkeigaku; 2017 Oct 27; 57(10):562-566. PubMed ID: 28954975.
    Abstract:
    We screened anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies among 42 patients who had undiagnosed chronic myopathy from six national hospitals. Anti-SRP and anti-HMGCR antibodies were determined by RNA immuneprecipitation and enzyme-linked immune-sorbent assay (ELISA), respectively. We identified two patients with anti-SRP antibodies (4.7%) and, two with anti-HMGCR antibodies (4.7%). Both of anti-SRP-positive patients showed dysphagia with a high level of creatine kinase. Anti-HMGCR antibodies were associated with mild muscle weakness with a relatively late disease onset. Our study suggests the importance of autoantibody testing among undiagnosed chronic myopathy.
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