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Title: Comparative amnestic effects of benzodiazepine hypnotic agents. Author: Scharf MB, Fletcher K, Graham JP. Journal: J Clin Psychiatry; 1988 Apr; 49(4):134-7. PubMed ID: 2895761. Abstract: The effects of triazolam 0.5 mg and temazepam 30 mg on immediate and delayed recall in normal and insomniac subjects were evaluated in three separate, randomized, placebo-controlled, parallel group studies. Neither drug caused significant impairment of immediate recall. In the tests of delayed recall, triazolam caused a consistent anterograde amnestic effect. No significant impairment of delayed recall was observed in the temazepam study. Anterograde amnesia is thought to be a dose-related effect of benzodiazepines. Compounds with high benzodiazepine receptor affinity such as triazolam are thought to cause this type of amnesia more often than the lower-affinity compounds such as temazepam.[Abstract] [Full Text] [Related] [New Search]