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  • Title: A zebrafish engrailed-like homeobox sequence expressed during embryogenesis.
    Author: Fjose A, Eiken HG, Njølstad PR, Molven A, Hordvik I.
    Journal: FEBS Lett; 1988 Apr 25; 231(2):355-60. PubMed ID: 2896133.
    Abstract:
    The zebrafish genome was found to contain two sequences which cross-hybridize strongly with the engrailed gene of Drosophila. Several independent clones containing one of these cross-hybridizing sequences were isolated from a zebrafish genomic library. Characterization of this region (ZF-EN) by DNA sequencing showed that it shares about 70% sequence identity with the engrailed homeobox. More extensive homeobox homology (greater than 90%) was found relative to the murine En genes. The closest relationship exists between ZF-EN and En-2 where the C-terminal domains (104 amino acids) encoded by these genes are almost identical. We also observed that ZF-EN and En-2 are very similar with respect to their transcript sizes and temporal expression patterns.
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