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  • Title: Effects of minaprine, a novel antidepressant, on prolactin secretion in the rat.
    Author: Matsuo N, Yamada K, Kumagai M, Nagashima M, Matsumoto S, Shirakawa K, Furukawa T.
    Journal: J Pharm Pharmacol; 1988 Jan; 40(1):66-8. PubMed ID: 2896781.
    Abstract:
    The effect of minaprine, a novel psychotropic drug with antidepressant properties, on prolactin secretion has been investigated in the rat. On intraperitoneal administration (10 and 20 mg kg-1) it significantly decreased basal prolactin levels. In contrast, both haloperidol (1 mg kg-1 i.p.) and morphine (20 mg kg-1 i.p.) increased serum prolactin levels and daily treatment with oestradiol (100 micrograms kg-1 s.c.) for 4 days also elevated the levels. Minaprine at a dose of 20 mg kg-1 failed to antagonize the elevation of serum prolactin levels induced by these drugs. The results imply that minaprine may not exert a direct inhibitory action on prolactin secretion at the pituitary gland.
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